转鼓
电泳剂
亲核细胞
化学
区域选择性
芳基
催化作用
羟胺
组合化学
镍
药物化学
有机化学
烯丙基重排
反应性(心理学)
烷基
病理
医学
替代医学
作者
Vincent van der Puyl,Joseph Derosa,Keary M. Engle
标识
DOI:10.1021/acscatal.8b04516
摘要
We report a regioselective, nickel-catalyzed syn-1,2-carboamination of nonconjugated alkenyl carbonyl compounds with O-benzoyl hydroxylamine (N–O) electrophiles and aryl/alkylzinc nucleophiles to afford β- and γ-amino acid derivatives. This method enables preparation of products containing structurally diverse tertiary amine motifs, including heterocycles, and can also be used to form quaternary carbon centers. The reaction takes advantage of a tethered 8-aminoquinoline directing group to control the regiochemical outcome and suppress two-component coupling between the N–O electrophile and organozinc nucleophile.
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