细胞生物学
内质网
线粒体分裂
运动性
线粒体融合
线粒体
功能(生物学)
细胞适应
生物
程序性细胞死亡
细胞凋亡
遗传学
线粒体DNA
基因
作者
Verónica Eisner,Martin Picard,György Hajnóczky
标识
DOI:10.1038/s41556-018-0133-0
摘要
Mitochondria sense and respond to many stressors and can support cell survival or death through energy production and signalling pathways. Mitochondrial responses depend on fusion–fission dynamics that dilute and segregate damaged mitochondria. Mitochondrial motility and inter-organellar interactions, such as with the endoplasmic reticulum, also function in cellular adaptation to stress. In this Review, we discuss how stressors influence these components, and how they contribute to the complex adaptive and pathological responses that lead to disease.
科研通智能强力驱动
Strongly Powered by AbleSci AI