应力颗粒
共域化
发病机制
RNA结合蛋白
多发性硬化
细胞质
失调家庭
翻译(生物学)
肌萎缩侧索硬化
核糖核酸
细胞生物学
生物
医学
信使核糖核酸
免疫学
病理
遗传学
基因
疾病
临床心理学
作者
Hannah E. Salapa,Chloe Johnson,Catherine Hutchinson,Bogdan F. Gh. Popescu,Michael C. Levin
标识
DOI:10.1016/j.jneuroim.2018.08.015
摘要
Dysfunction of the RNA binding protein (RBP) heterogeneous nuclear ribonuclear protein A1 (hnRNP A1) has been shown to contribute to the pathogenesis of neurodegenerative diseases, but its involvement in multiple sclerosis (MS) is largely unknown. In a neuronal cell line, interferon-γ caused hnRNP A1 nucleocytoplasmic mislocalization; colocalization of hnRNP A1 in stress granules (SGs); and inhibition of translation. Neurons in the brain of a MS patient showed pathogenic RBP dysfunction, including nuclear depletion of hnRNP A1, its mislocalization to the cytoplasm, and its colocalization in SGs. These data indicate a role for dysfunctional hnRNP A1 in the pathogenesis of MS.
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