多囊卵巢
胰岛素抵抗
氧化应激
内分泌学
生物
内科学
脂质代谢
不育
内分泌系统
活性氧
激素
海西定
医学
糖尿病
生物信息学
细胞生物学
怀孕
贫血
遗传学
作者
Min Wang,Bo-Qi Zhang,Shuai Ma,Ying Xu,Dong-Hai Zhao,Jingshun Zhang,Chun-Jin Li,Xu Zhou,Lianwen Zheng
标识
DOI:10.3389/fendo.2024.1390013
摘要
Polycystic ovarian syndrome (PCOS) is a common heterogeneous reproductive endocrine metabolic disorder in women of reproductive age characterized by clinical and biochemical hyperandrogenemia, ovulation disorders, and polycystic ovarian morphology. Ferroptosis is a novel type of cell death driven by iron accumulation and lipid peroxidation. Ferroptosis plays a role in maintaining redox balance, iron metabolism, lipid metabolism, amino acid metabolism, mitochondrial activity, and many other signaling pathways linked to diseases. Iron overload is closely related to insulin resistance, decreased glucose tolerance, and the occurrence of diabetes mellitus. There is limited research on the role of ferroptosis in PCOS. Patients with PCOS have elevated levels of ferritin and increased reactive oxygen species in ovarian GCs. Studying ferroptosis in PCOS patients is highly important for achieving personalized treatment. This article reviews the progress of research on ferroptosis in PCOS, introduces the potential connections between iron metabolism abnormalities and oxidative stress-mediated PCOS, and provides a theoretical basis for diagnosing and treating PCOS.
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