医学
肝细胞癌
内科学
胃肠病学
不良事件通用术语标准
不利影响
佐剂
比例危险模型
单变量分析
危险系数
肿瘤科
多元分析
置信区间
作者
Lu-Yun Yuan,Jin-Kai Feng,Yuqing Zhang,Chongde Lu,Xu Liu,Chao Liang,Zong-Han Liu,Feifei Mao,Yan-Jun Xiang,Weijun Wang,Kang Wang,Shuqun Cheng
出处
期刊:Ejso
[Elsevier]
日期:2023-07-01
卷期号:49 (7): 1226-1233
被引量:4
标识
DOI:10.1016/j.ejso.2023.01.020
摘要
This study aimed to assess the efficacy and safety of postoperative adjuvant transarterial chemoembolization (PA-TACE) plus immune checkpoint inhibitor (ICI) for hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT).This study was conducted on three centers from June 2018 to December 2020. Patients were divided into the PA-TACE (n = 48) and PA-TACE plus ICI groups (n = 42). The recurrence-free survival (RFS) and overall survival (OS) curves were depicted by Kaplan-Meier method, and the differences between the two groups were compared using log-rank test. Univariate and multivariate Cox analyses were performed to identify independent risk factors for RFS and OS. Adverse events (AEs) were assessed according to the Common Terminology Criteria for AEs (CTCAE) version 5.0.The median RFS of the PA-TACE plus ICI group was significantly longer than the PA-TACE group (12.76 months vs. 8.11 months; P = 0.038). The median OS of the PA-TACE plus ICI group was also significanfly better than the PA-TACE group (24.5 months vs. 19.1 months; P = 0.032). PA-TACE plus ICI treatment was an independent prognostic factor for RFS (HR: 0.54, 95% CI: 0.32-0.9, P = 0.019) and OS (HR: 0.47, 95% CI: 0.26-0.86, P = 0.014). Only one patient experienced grade ≥3 immune-related AEs in the PA-TACE plus ICI group.PA-TACE plus ICI treatment had better efficacy in preventing recurrence and prolonging survival than PA-TACE alone for HCC patients with PVTT after R0 resection. This novel treatment modality may be an appropriate option for HCC with PVTT.
科研通智能强力驱动
Strongly Powered by AbleSci AI