材料科学
聚己内酯
阿霉素
催化作用
纳米纤维
体内
化疗
癌症研究
纳米技术
医学
内科学
化学
生物化学
生物
聚合物
复合材料
生物技术
作者
Minjia Zheng,Shuncheng Yao,Yunchao Zhao,Xingyi Wan,Quanhong Hu,Chuyu Tang,Zhuoheng Jiang,Shaobo Wang,Zhongfan Liu,Linlin Li
标识
DOI:10.1021/acsami.2c21878
摘要
The efficacy of cancer catalytic therapy is still hindered by the inefficient generation of reactive oxygen species (ROS). Herein, we report a self-driven electrical stimulation-promoted cancer catalytic therapy and chemotherapy by integrating a human-driven triboelectric nanogenerator (TENG) with an implantable and biodegradable nanofibrous patch. The gelatin/polycaprolactone nanofibrous patch incorporates doxorubicin (DOX) and graphitic carbon nitride (g-C3N4), in which the peroxidase (POD)-like activity of g-C3N4 to produce hydroxyl radical (•OH) can be distinctly enhanced by the self-driven electrical stimulation for 4.12-fold, and simultaneously DOX can be released to synergize the therapy, especially under a weakly acidic tumor microenvironment (TME) condition. The in vitro and in vivo experimental results on a mouse breast cancer model demonstrate superior tumor suppression outcome. The self-powered electrical stimulation-enhanced catalytic therapy and chemotherapy via multifunctional nanofibrous patches proposes a new complementary strategy for the catalytic therapy of solid tumors.
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