聚乙烯吡咯烷酮
化学
壳聚糖
磁铁矿
抗菌活性
催化作用
组合化学
还原剂
对接(动物)
大肠杆菌
核化学
纳米颗粒
纳米技术
材料科学
细菌
有机化学
生物化学
基因
护理部
生物
医学
冶金
遗传学
作者
Ayesha Ayesha,Muhammad Imran,Ali Haider,Iram Shahzadi,Sawaira Moeen,Anwar Ul‐Hamid,Walid Nabgan,Anum Shahzadi,Thamraa Alshahrani,Muhammad Ikram
标识
DOI:10.1016/j.jece.2023.110088
摘要
This work presents the synthesis of polyvinylpyrrolidone (PVP) and chitosan (CS) coated magnetite (Fe3O4) nanoparticles (NPs) by co-precipitation technique. The objective of this research was to investigate the catalytic, antibacterial efficacy with evidential molecular docking analysis of CS/PVP- Fe3O4 and PVP/CS- Fe3O4. The coating of PVP and CS reduced the particle size of Fe3O4, providing a large surface area that increased catalytic and antibacterial potency. These binary coated magnetite NPs used as ideal catalytic agent for the reduction of rhodamine B dye as well as antibacterial agent against Escherichia coli. The findings of a molecular docking investigation were in reasonable accord with in vitro microbicidal activity and revealed that CS-Fe3O4, Fe3O4-doped PVP and CS are promising inhibitors of dihydrofolate reductaseE. Coli (DHFR) and DNA gyraseE. Coli.
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