医学
硫代硫酸钠
耳毒性
肿瘤科
随机对照试验
比例(比率)
临床试验
内科学
临床肿瘤学
顺铂
化疗
癌症
量子力学
物理
无机化学
化学
作者
Etan Orgel,Keith Knight,Doojduen Villaluna,Mark Krailo,Adam J. Esbenshade,Lillian Sung,David R. Freyer
摘要
Abstract In two randomized trials (Children's Oncology Group ACCL0431 and International Childhood Liver Tumour Strategy Group SIOPEL‐6), sodium thiosulfate (STS) demonstrated efficacy in preventing cisplatin‐induced hearing loss (CIHL). However, the measures used in those trials have been superseded by the consensus International Society of Paediatric Oncology (SIOP) Ototoxicity Scale. To provide benchmark data for STS efficacy when using this contemporary scale, we reanalyzed ACCL0431 hearing outcomes with the SIOP scale and using multiple timepoints. Compared to the control arm, STS significantly reduced CIHL when assessed by the SIOP scale across these different approaches. These results provide critical data to inform treatment discussions and support future potential trial designs comparing otoprotectants.
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