Synthesis of anisotropic gold nanoparticles in binary surfactant mixtures: a review on mechanisms of particle formation

Gold nanoparticles are promising candidates for a wide spectrum of biomedical applications ranging from diagnostics and sensors to therapeutics. Their plasmonic properties are dependent on their size and shape among other factors, which can be controlled by understanding various growth mechanisms. Since the breakthrough of the seed-mediated growth approach reported in 2001, the scientific community has actively engaged in the synthesis of tailored anisotropic gold nanoparticles. Surfactants are known for their shape-controlling abilities and since Nikoobakht and El-Sayed in 2003 used a binary surfactant mixture, this method has been adopted as a common synthesis strategy. A wide range of particle shapes have been produced in binary surfactant mixtures using different synthesis approaches, and different working mechanisms have been proposed. This calls for a thorough and critical evaluation of the synthetic methods with an aim to bridge the link between the use of binary surfactants and the control of morphology of anisotropic gold nanoparticles. This review gives a systematic overview of experimental procedures using binary surfactant mixtures to produce gold nanoparticles with tuned properties. The resulting shapes include gold nanorods, bipyramids, tetrahexahedra, and other anisotropic structures. Different mechanisms proposed based on experimental, simulation and modelling analyses are discussed based on the type of binary surfactant systems. Current challenges that need to be addressed and future prospects that may open up new avenues of applications for anisotropic gold nanoparticles are also discussed.