微尺度化学
小型化
微流控
纳米技术
量子传感器
实验室晶片
量子
计算机科学
微加工
材料科学
量子计算机
嵌入式系统
量子模拟器
物理
制作
数学教育
病理
医学
量子力学
数学
替代医学
作者
Robin D. Allert,Fleming Bruckmaier,Nick Ruben Neuling,Fabian Alexander Freire-Moschovitis,K S Liu,C Schrepel,Philip Schätzle,Peter Knittel,M Hermans,Dominik B. Bucher
出处
期刊:Lab on a Chip
[The Royal Society of Chemistry]
日期:2022-01-01
被引量:6
摘要
Lab-on-a-chip (LOC) applications have emerged as invaluable physical and life sciences tools. The advantages stem from advanced system miniaturization, thus, requiring far less sample volume while allowing for complex functionality, increased reproducibility, and high throughput. However, LOC applications necessitate extensive sensor miniaturization to leverage these inherent advantages fully. Atom-sized quantum sensors are highly promising to bridge this gap and have enabled measurements of temperature, electric and magnetic fields on the nano- to microscale. Nevertheless, the technical complexity of both disciplines has so far impeded an uncompromising combination of LOC systems and quantum sensors. Here, we present a fully integrated microfluidic platform for solid-state spin quantum sensors, like the nitrogen-vacancy (NV) center in diamond. Our platform fulfills all technical requirements, such as fast spin manipulation, enabling full quantum sensing capabilities, biocompatibility, and easy adaptability to arbitrary channel and chip geometries. To illustrate the vast potential of quantum sensors in LOC systems, we demonstrate various NV center-based sensing modalities for chemical analysis in our microfluidic platform, ranging from paramagnetic ion detection to high-resolution microscale NV-NMR. Consequently, our work opens the door for novel chemical analysis capabilities within LOC devices with applications in electrochemistry, high-throughput reaction screening, bioanalytics, organ-on-a-chip, or single-cell studies.
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