Metal-Free Selective Ortho-C–H Amidation of Hypervalent(III) Iodobezenes with N-Methoxy Amides under Mild Conditions

A metal-free selective ortho-C-H amidation of aryl iodines(III) with the use of N-methoxy amides as aminating reagents under mild conditions is described here. In the protocol, excellent chemoselectivity and high regioselectivity were obtained. Notably, the iodine substituent rendered the amidation product suitable to be used for further elaboration.