自愈水凝胶
医学
粘附
外体
细胞生物学
外科
生物医学工程
微泡
化学
生物
生物化学
高分子化学
小RNA
有机化学
基因
作者
Ling Wang,Peier Chen,Yuxuan Pan,Z J Wang,Jie Xu,Xiaoqi Wu,Qiao Yang,Meng Long,Sitian Liu,Wenhua Huang,Caiwen Ou,Yaobin Wu
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2023-08-04
卷期号:9 (31)
被引量:7
标识
DOI:10.1126/sciadv.adh1753
摘要
Postsurgical pericardial adhesions pose increased risks of sequelae, prolonged reoperation time, and reduced visibility in the surgical field. Here, we introduce an injectable Janus hydrogel, which exhibits asymmetric adhesiveness properties after photocrosslinking, sustained delivering induced pluripotent stem cell–derived cardiomyocyte exosomes (iCM-EXOs) for post–heart surgery adhesion reduction. Our findings reveal that iCM-EXOs effectively attenuate oxidative stress in hydrogen peroxide–treated primary cardiomyocytes by inhibiting the activation of the transcription factor nuclear factor erythroid 2–related factor 2. Notably, in rat cardiac postsurgery models, the Janus hydrogels loaded with iCM-EXOs demonstrate dual functionality, acting as antioxidants and antipericardial adhesion agents. These hydrogels effectively protect iCM-EXOs from GATA 6+ cavity macrophage clearance by inhibiting the recruitment of macrophages from the thoracic cavity. These results highlight the promising potential of iCM-EXO–laden Janus hydrogels for clinical safety and efficacy validation in trials involving heart surgery patients, with the ultimate goal of routine administration during open-heart surgeries.
科研通智能强力驱动
Strongly Powered by AbleSci AI