Impact of highly effective modulator therapy on chronic rhinosinusitis and health status: 2-year follow-up

•HEMT improves multiple measures of sinusitis through 2 years of therapy in adults.•Sinus CT scans analyzed via machine learning methods and sinus symptoms improved.•Health utility increased and productivity loss decreased with 24 months of HEMT.•HEMT initiated in adulthood did not fully resolve chronic rhinosinusitis in adults.