Interoceptive Neural Circuits Mediating the Progression from Somatic Diseases to Comorbid Depression

The INC, particularly the L-VDC, plays a crucial role in the pathogenesis of depression and the intersection of somatic diseases. The INC mediates the progression from somatic diseases to comorbid depression, suggesting that interventions targeting the INC may prevent and alleviate the burden of comorbid somatic diseases and depression.