Development of a compound herbal formulation (HBK) with antitumor and antioxidant functions for cancer adjuvant therapy

This study provides a comprehensive evaluation of a TCM-based multi-herb formulation for its immunomodulatory and antioxidant effects in lung cancer. HBK significantly enhanced anti-tumor immunity, increased antioxidant enzyme and cytokine activity, and remodeled the tumor microenvironment. Notably, these effects were mediated through inhibition of the TLR3/NF-κB signaling pathway. While individual herbal components have previously been linked to this pathway, our study is the first to demonstrate that a TCM-based multi-herb formula can modulate tumor immunity via TLR3/NF-κB inhibition in vivo.