糖原
糖尿病
2型糖尿病
内科学
内分泌学
平衡
葡萄糖稳态
化学
生物
医学
胰岛素抵抗
作者
Ziyi Wang,Xin Min,Zhenxia Hu,Mitchell A. Sullivan,Yong Tang,Liang Wang,Robert G. Gilbert,Chen Shi,Bin Deng
标识
DOI:10.1016/j.ijbiomac.2022.08.212
摘要
Liver glycogen is a highly branched glucose polymer found as β particles (~20 nm in diameter), which can bind together into larger composite α particles. Hepatic α particles have been shown to be structurally fragile (breaking up into smaller particles in certain solvents) in mouse models of diabetes; if occurring in vivo, the resulting small glycogen particles could exacerbate the poor blood-sugar homeostasis characteristic of the disease. Here we tested if this α-particle fragility also occurred in liver glycogen obtained from humans with diabetes. It was found that liver glycogen from diabetic humans was indeed more fragile than from non-diabetic humans, which was also seen in the mouse experiments we ran in parallel. Proteomic analysis revealed three candidate proteins from differentially expressed glycogen proteins (Diabetes/ Non-diabetes) in both human and mouse groups. Identifying these proteins may give clues to the binding mechanism that holds together α particles together, which, being different in diabetic glycogen, is relevant to diabetes prevention and management.
科研通智能强力驱动
Strongly Powered by AbleSci AI