疾病
神经退行性变
雌激素受体α
雌激素受体
雌激素受体
背景(考古学)
医学
内科学
生物信息学
骨质疏松症
炎症
内分泌学
雌激素
生物
癌症研究
癌症
乳腺癌
古生物学
作者
Min Jia,Karin Dahlman-Wright,Jan‐Åke Gustafsson
标识
DOI:10.1016/j.beem.2015.04.008
摘要
Estrogen receptors alpha (ERα) and beta (ERβ) are transcription factors that are involved in the regulation of many complex physiological processes in humans. Abnormal ER signaling leads to development of a variety of diseases, such as cancer, metabolic and cardiovascular disease, neurodegeneration, inflammation, and osteoporosis. This review provides an overview and update on ERα and ERβ in health and disease with focus on their role in cancer and metabolic disease and in the context of recent years' success in providing genome wide data on ER function. Furthermore, potential clinical applications and challenges are also discussed.
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