介孔二氧化硅
药物输送
乙二醇
纳米颗粒
PEG比率
光子上转换
材料科学
纳米复合材料
纳米技术
细胞毒性
化学
发光
化学工程
核化学
介孔材料
有机化学
体外
生物化学
光电子学
工程类
财务
经济
催化作用
作者
Chunxia Li,Zhiyao Hou,Yunlu Dai,Dongmei Yang,Ziyong Cheng,Ping’an Ma,Jun Lin
出处
期刊:Biomaterials Science
[The Royal Society of Chemistry]
日期:2013-01-01
卷期号:1 (2): 213-223
被引量:109
摘要
Upconversion luminescent β-NaYF4:Yb3+, Er3+ nanoparticles (UCNPs) were encapsulated with uniform mesoporous silica shells, which were further modified with poly(ethylene glycol) (PEG) and cancer-targeting ligand folic acid (FA), resulting in the formation of water-dispersible and biologically functionalized core–shell structured UCNPs@mSiO2 nanoparticles with an overall average size of around 80 nm. The obtained multifunctional nanocomposite spheres can be performed as an anti-cancer drug delivery carrier and applied for cell imaging. It is found that anti-cancer drug doxorubicin hydrochloride (DOX) can be absorbed into UCNPs@mSiO2-PEG/FA nanospheres and released in a pH-sensitive pattern. In vitro cell cytotoxicity tests on cancer cells verified that DOX-loaded UCNPs@mSiO2-PEG/FA nanospheres exhibited greater cytotoxicity with respect to free DOX and DOX-loaded UCNPs@mSiO2-PEG at the same concentrations, owing to the increase of cell uptake of anti-cancer drug delivery vehicles mediated by the FA receptor. Moreover, the upconversion luminescence image of UCNPs@mSiO2-PEG/FA taken up by cells shows green emission under 980 nm infrared laser excitation, making the UCNPs@mSiO2-PEG/FA nanocomposite spheres promising candidates as bioimaging agents. These findings highlight the promise of the highly versatile multifunctional nanoparticles for simultaneous imaging and therapeutic applications.
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