Catalytic Oxidation of C(sp3)H Bonds Induced by a Radical Cation Salt: Construction of 1,4‐Dihydropyridines Using a Fragment‐Reassembly Strategy

Abstract A fragment‐reassembly strategy was applied to the construction of 1,4‐dihydropyridines and phosphorus‐substituted 1,4‐dihydropyridines under catalytic radical cation salt‐induced C(sp)3H functionalization of glycine derivatives. Mechanistic studies show that domino C(sp)3H bond oxidation and CN bond cleavage reactions are involved. magnified image