Swirl-Based Control Method of Cell Orientation-Impact on Control Performance with Eccentricity

The adjustment of cell position and orientation is important in cell micromanipulation of bioengineering, which directly affects the efficiency and success ratio of the micromanipulation. Cell orientation can be adjusted by swirl, which comes from a pair of parallel opposite micro-fluids from two tiny tubes, and the cell in swirl center will rotate. Quantitative control of rotation angle and velocity of the cell can be achieved by adjusting the velocity and frequency of micro-fluid. This control method of cell orientation has prospective applications for its non-contact characteristics. However, cell will not be right in the swirl center in practical operations. And if the eccentric cell can rotate steadily, swirl method will be more reliable. So numerical simulation was conducted to study the movement trajectory of cells with eccentricity, and the influences of eccentric directions and eccentric distances were discussed. The simulation results indicate the feasibility of orientation control of cells with eccentricity by swirl.