谷氨酸受体
生物化学
氨基酸
代谢型谷氨酸受体
谷氨酸
代谢型谷氨酸受体6
生物
化学
代谢型谷氨酸受体1
代谢型谷氨酸受体7
代谢型谷氨酸受体5
受体
作者
John T. Brosnan,Margaret E. Brosnan
出处
期刊:Amino Acids
[Springer Nature]
日期:2012-04-18
卷期号:45 (3): 413-418
被引量:223
标识
DOI:10.1007/s00726-012-1280-4
摘要
Glutamate is one of the most abundant of the amino acids. In addition to its role in protein structure, it plays critical roles in nutrition, metabolism and signaling. Post-translational carboxylation of glutamyl residues increases their affinity for calcium and plays a major role in hemostasis. Glutamate is of fundamental importance to amino acid metabolism, yet the great bulk of dietary glutamate is catabolyzed within the intestine. It is necessary for the synthesis of key molecules, such as glutathione and the polyglutamated folate cofactors. It plays a major role in signaling. Within the central nervous system, glutamate is the major excitatory neurotransmitter and its product, GABA, the major inhibitory neurotransmitter. Glutamate interaction with specific taste cells in the tongue is a major component of umami taste. The finding of glutamate receptors throughout the gastrointestinal tract has opened up a new vista in glutamate function. Glutamate is truly a functional amino acid.
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