质子
辐照
激光器
相对生物效应
光束线
原子物理学
核磁共振
化学
放射化学
梁(结构)
核物理学
物理
光学
作者
Akifumi Yogo,Takahiro Maeda,T. Hori,H. Sakaki,Koichi Ogura,Mamiko Nishiuchi,A. Sagisaka,Hiromitsu Kiriyama,Hajime Okada,Shuhei Kanazawa,Takuya Shimomura,Yoshiki Nakai,Manabu Tanoue,Fumitaka Sasao,Paul R. Bolton,M. Murakami,Takayoshi Nomura,Shunichi Kawanishi,Kiminori Kondo
摘要
Human cancer cells are irradiated by laser-driven quasimonoenergetic protons. Laser pulse intensities at the 5×1019 W/cm2 level provide the source and acceleration field for protons that are subsequently transported by four energy-selective dipole magnets. The transport line delivers 2.25 MeV protons with an energy spread of 0.66 MeV and a bunch duration of 20 ns. The survival fraction of in vitro cells from a human salivary gland tumor is measured with a colony formation assay following proton irradiation at dose levels of up to 8 Gy, for which the single bunch dose rate is 1×107 Gy/s and the effective dose rate is 0.2 Gy/s for 1 Hz repetition of irradiation. Relative biological effectiveness at the 10% survival fraction is measured to be 1.20±0.11 using protons with a linear energy transfer of 17.1 keV/μm.
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