医学
血液透析
德诺苏马布
终末期肾病
重症监护医学
阶段(地层学)
肾脏疾病
终末期肾病
泌尿科
内科学
骨质疏松症
生物
古生物学
作者
Mohammad F Zaitoun,Khalid Al-Alsheikh,W. Elnazer
出处
期刊:Clinical Nephrology
[Dustri-Verlag Dr. Karl Feistle]
日期:2021-12-01
卷期号:96 (6): 353-356
被引量:1
摘要
Background There is limited evidence on the safety and efficacy of denosumab for the management of immobilization-related hypercalcemia in hemodialysis patients. We report a case of successful treatment of immobilization-related hypercalcemia with a high dose of denosumab (120 mg). Case presentation A 55-year-old, bed-ridden woman was admitted to the intensive care unit with suspected catheter-related bacteremia and septic shock. 13 days following admission, the patient's corrected serum calcium levels rose from 2.52 mmol/L at baseline to 3.39 mmol/L. Cinacalcet, subcutaneous calcitonin, intravenous zoledronic acid, and subcutaneous 60-mg dose of denosumab were administered but resulted in an inadequate response. Consequently, subcutaneous 120-mg dose of denosumab was administered and resulted in a gradual decline of corrected serum calcium levels from 4.18 mmol/L to 2.45 mmol/L within 3 weeks; corrected serum calcium levels were maintained above 2.10 mmol/L and less than 2.80 mmol/L for 3 months after high-dose denosumab administration. Conclusion High-dose denosumab could be a viable treatment option for end-stage renal disease patients developing immobilization-related hypercalcemia.
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