比例(比率)
放大
过程(计算)
环境科学
工艺工程
计算机科学
工程类
物理
量子力学
经典力学
操作系统
作者
Ralph Zhao,Theodore R. Furman,Megan Roth
标识
DOI:10.1021/acs.oprd.1c00360
摘要
Process safety testing is critical for small molecule active pharmaceutical ingredient (API) scale-up and manufacturing by proactively identifying any process safety hazards, including environmental and industrial hygiene issues. The intent of this contribution is to describe how Merck & Co., Inc. Kenilworth, NJ (known as MSD outside of the U.S. and Canada) manages process safety testing for pilot plant and manufacturing scale operations with a stagewise approach. Several case studies will be discussed.
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