维生素连接蛋白
转染
化学
全身给药
内生
药物输送
分子生物学
细胞生物学
整合素
生物物理学
细胞
生物化学
生物
体内
基因
生物技术
有机化学
作者
Dongyu Chen,Shanthi Ganesh,Weimin Wang,Adrien Lupieri,Mansoor M. Amiji
出处
期刊:Nanomedicine
日期:2021-03-01
卷期号:16 (7): 535-551
被引量:12
标识
DOI:10.2217/nnm-2020-0428
摘要
Aim: To evaluate the role of vitronectin-enriched protein corona on systemic delivery of siRNA-encapsulated cationic lipid nanoparticles (LNPs) to αvβ3 integrin expressing solid tumors. Materials & methods: 1,2-Dioleoyl-3-trimethylammonium-propane LNPs were formulated, protein corona formed in nude mice serum and its impact on drug delivery were analyzed. Results: 1,2-Dioleoyl-3-trimethylammonium-propane-containing LNP led to enhanced recruitment of vitronectin and showed preferential transfection to αvβ3-expressed cells relative to controls. Upon systemic administration in mice, the LNPs accumulated in the αvβ3-expressing endothelial lining of the tumor blood vessels before reaching tumor cells. Conclusion: These results present an optimized LNP that selectively recruits endogenous proteins in situ to its corona which may lead to enhanced delivery and transfection in tissues of interest.
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