癌症干细胞
癌症研究
干细胞标记物
同源盒蛋白纳米
神经球
SOX2
CD44细胞
胶质瘤
成体干细胞
癌症
癌细胞
细胞
转移
间充质干细胞
祖细胞
细胞生长
胶质母细胞瘤
边居
神经干细胞
肿瘤微环境
作者
Jessica Tilghman,Hao Wu,Yingying Sang,Xiaohai Shi,Hugo Guerrero-Cazares,Alfredo Quiñones-Hinojosa,Charles G. Eberhart,John Laterra,Mingyao Ying
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2014-06-01
卷期号:74 (11): 3168-3179
被引量:68
标识
DOI:10.1158/0008-5472.can-13-2103
摘要
Glioblastoma (GBM) stem cells (GSC) are a subpopulation of tumor cells that display stem-like characteristics (stemness) and play unique roles in tumor propagation, therapeutic resistance, and tumor recurrence. Therapeutic targets in GSCs are a focus of increasing interest to improve GBM therapy. Here we report that the hyaluronan-mediated motility receptor (HMMR) is highly expressed in GBM tumors, where it supports the self-renewal and tumorigenic potential of GSCs. HMMR silencing impairs GSC self-renewal and inhibits the expression of GSC markers and regulators. Furthermore, HMMR silencing suppresses GSC-derived tumor growth and extends the survival of mice bearing GSC xenografts. Conversely, HMMR overexpression promotes GSC self-renewal and intracranial tumor propagation. In human GBM tumor specimens, HMMR expression is correlated positively with the expression of stemness-associated markers and regulators. Our findings identify HMMR as a candidate therapeutic target to GSCs as a GBM treatment strategy.
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