自身免疫
T细胞
细胞生物学
功能(生物学)
免疫
生物
周边公差
免疫学
受体
细胞
T细胞受体
免疫系统
程序性细胞死亡
细胞凋亡
化学
生物化学
作者
Arlene H. Sharpe,E. John Wherry,Rafi Ahmed,Gordon J. Freeman
摘要
The programmed cell death 1 (PD-1) surface receptor binds to two ligands, PD-L1 and PD-L2. Studies have shown that PD-1-PD-L interactions control the induction and maintenance of peripheral T cell tolerance and indicate a previously unknown function for PD-L1 on nonhematopoietic cells in protecting tissues from autoimmune attack. PD-1 and its ligands have also been exploited by a variety of microorganisms to attenuate antimicrobial immunity and facilitate chronic infection. Here we examine the functions of PD-1 and its ligands in regulating antimicrobial and self-reactive T cell responses and discuss the therapeutic potential of manipulating this pathway.
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