内科学
PCSK9
内分泌学
载脂蛋白B
可欣
胆固醇
血脂异常
2型糖尿病
糖尿病
2型糖尿病
医学
生物
低密度脂蛋白受体
脂蛋白
作者
Martijn C.G.J. Brouwers,Jason S. Troutt,Marleen M. J. van Greevenbroek,Isabel Ferreira,Edith J. M. Feskens,Carla Kallen,Nicolaas C. Schaper,Casper G. Schalkwijk,Robert J. Konrad,Coen D. A. Stehouwer
标识
DOI:10.1016/j.atherosclerosis.2011.03.023
摘要
ObjectiveType 2 diabetes mellitus (T2DM) is associated with elevated plasma apolipoprotein B and triglycerides levels, reduced HDL cholesterol and the presence of small-dense LDL particles. The present study was conducted to investigate the role of plasma proprotein convertase subtilisin kexin type 9 (PCSK9) levels, a regulator of LDL-receptor expression, in the occurrence of diabetic dyslipidemia.MethodsPlasma PCSK9 was measured in a cohort of subjects with normal glucose metabolism (NGM; n = 288), impaired glucose metabolism (IGM; n = 121) and type 2 diabetes mellitus (T2DM; n = 139) to study whether its relation with plasma apolipoprotein B, triglycerides, total cholesterol, non-HDL cholesterol, LDL cholesterol and HDL cholesterol differed by levels of glucose metabolism status.ResultsPlasma PCSK9 levels were not different between the three groups (82, 82 and 80 ng/mL in NGM, IGM and T2DM, respectively). PCSK9 was positively associated with total cholesterol, non-HDL cholesterol, LDL cholesterol, apolipoprotein B and triglycerides levels in all subgroups. The regression slopes for the associations with non-HDL cholesterol were steeper among individuals with T2DM than with NGM (β = 0.016 versus β = 0.009, p-interaction = 0.05). Similar results were obtained for the relation with apolipoprotein B (β = 0.004 versus β = 0.002, p-interaction = 0.09).ConclusionsAlthough glucose metabolism status per se is not associated with plasma PCSK9 levels, the presence of T2DM may modify the relation between plasma PCSK9 and non-HDL cholesterol and apolipoprotein B. These observations should be regarded as hypothesis generating for further studies aimed at elucidating the role of PCSK9 in the pathogenesis and treatment of diabetic dyslipidemia.
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