生物膜
微生物学
绿脓素
自诱导物
群体猝灭
毒力因子
生物
作者
Cenbin Lu,Christine K. Maurer,Benjamin Kirsch,Anke Steinbach,Rolf W. Hartmann
标识
DOI:10.1002/anie.201307547
摘要
The virulence regulator PqsR of Pseudomonas aeruginosa is considered as an attractive target for attenuating the bacterial pathogenicity without eliciting resistance. However, despite efforts and desires, no promising PqsR antagonist has been discovered thus far. Now, a surprising functionality change of a highly affine PqsR antagonist in P. aeruginosa is revealed, which is mediated by a bacterial signal molecule synthase and responsible for low cellular potency. Blockade of the susceptible position led to the discovery of the first antivirulence compound that is potent in vivo and targets PqsR, thus providing a proof of concept for this novel antivirulence therapy.
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