马普替林
米安色林
诺曲普利
地昔帕明
多塞平
丙咪嗪
化学
阿米替林
药理学
抗抑郁药
色谱法
医学
内科学
病理
替代医学
海马体
作者
David Attwood,Jenny Louise Gibson
标识
DOI:10.1111/j.2042-7158.1978.tb13192.x
摘要
Abstract Light scattering, conductivity and pH methods have been used to examine the aggregation in aqueous solution of a series of antidepressant drugs. The drugs investigated included the hydrochlorides of amitriptyline, butriptyline, protriptyline, nortriptyline, imipramine, desipramine, clomipramine, dothiepin, dibenzepin, opipramol, iprindole, doxepin, mianserin and maprotiline. No significant association of dibenzepin, mianserin or maprotiline hydrochlorides could be detected up to their respective solubility limits. A micellar pattern of association was established for all other compounds. Critical micelle concentrations and micellar properties are reported.
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