Abnormal liver enzyme‐mediated metabolism in Parkinson's disease

If toxicant exposure contributes to the cause of Parkinson9s disease, poor function of detoxifying enzymes could increase vulnerability for Parkinson9s disease. Although no hepatic enzyme system has been shown universally to be dysfunctional in Parkinson9s disease patients, several have been suggested to be dysfunctional in subgroups, such as those with young age at disease onset. Specific enzymes implicated include several P450 enzymes, most notably P450 IID6, and cysteine dioxygenase. If hepatic enzyme abnormalities contribute to the development of Parkinson9s disease, molecular genetic tech-niques may allow the development of screening testa to identify at-risk subjects in order to intervene with protective therapies.