雷公藤碱
恐惧条件反射
心理学
经典条件反射
敌手
条件作用
多巴胺
神经科学
冻结行为
多巴胺受体D2
扁桃形结构
发展心理学
受体
内科学
医学
统计
数学
表号:SCH-23390
作者
Fay A. Guarraci,Russell J. Frohardt,William A. Falls,Bruce S. Kapp
标识
DOI:10.1037//0735-7044.114.3.647
摘要
The present study examined the effects of bilateral intra-amygdaloid infusions of the D2 receptor antagonist, eticlopride, on the acquisition and expression of Pavlovian fear conditioning as measured by freezing to acoustic and background contextual stimuli in the rat. Infusions of eticlopride before acquisition or before both acquisition and retention testing significantly attenuated conditioned freezing to tone presentations during the retention test 24 hr later. No effects, however, were observed on freezing that emerged during acquisition. Furthermore, these effects were not attributable to state-dependent learning effects or alterations in baseline activity or shock reactivity. In conclusion, these results suggest that amygdaloid dopamine transmission at D2 receptors contributes to the formation and/or consolidation of fear memories.
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