Renal and Spermatozoal Toxicity of α-Bromohydrin, 3-Bromolactate and 3-Bromopyruvate

(R,S)- and (R)-3-Bromopropan-1,2-diol (α-bromohydrin) produced diuresis and glucosuria when administered to male rats but had no effect on the metabolic activity of rat kidney tubules in vitro. The oxidation products (R,S)-3-bromolactate and 3-bromopyruvate produced brief phases of diuresis but not glucosuria, and severely inhibited the metabolic activity of rat kidney tubules in vitro. α-Bromohydrin had no effect on the metabolic activity of boar spermatozoa whereas the oxidation products severely affected mitochondrial metabolism. 3-Bromopyruvate also inhibited boar spermatozoal glyceraldehyde 3-phosphate dehydrogenase.