Correlation of the Absolute Configuration of Chiral Epoxides by Complexation Chromatography; Synthesis and Enantiomeric Purity of (+)‐ and (−)‐1,2‐Epoxypropane

Chiroptical properties of chiral substrates can be determined by complexation chromatography. 10-9 g of crude, non-derivatized substance suffice for determination of optical purity; the rotation of the pure enantiomer need not be known. Moreover, the absolute configuration of three-membered ring heterocycles can be deduced from their retention behavior on a special nickel complex with the aid of a quadrant rule for (1), XNH, O, S.