基质金属蛋白酶
伤口愈合
金属蛋白酶组织抑制剂
医学
人体皮肤
水泡
基质金属蛋白酶9
酶
药理学
化学
免疫学
内科学
生物化学
生物
遗传学
作者
Matthew J. Reiss,Yuan‐Ping Han,W.L. Garner
标识
DOI:10.1111/j.1524-475x.2009.00476.x
摘要
ABSTRACT Matrix metalloproteinase‐9 (MMP‐9) plays a central role in many physiologic processes including acute and the chronic wounds. MMP‐9 is not routinely expressed in healthy tissues but is promptly expressed as a proenzyme and converted into active enzyme after tissue injury. The mechanisms involved, including the activators and inhibitors for this enzyme in human tissue remain largely obscure. We recently identified α1‐antichymotrypsin (α1‐ACT), an acute phase factor, as a potent inhibitor controlling activation of pro‐MMP‐9 by human skin. The aim of this study is to establish the clinical relevance of the inhibitor in cutaneous wound healing. Fluids from acute burn blisters and conditioned media from skin explants of burn patients were analyzed. We observed that the presence pro‐MMP‐9 and its activation correlated with the proximity to and degree of injury. Early after trauma, massive levels of wound α1‐ACT were associated with an absence of pro‐MMP‐9 activation. Conversely, the active MMP‐9 occurs simultaneously with inactivation of α1‐ACT. Our results suggest a role for α1‐ACT as a physiologic inhibitor of MMP‐9 activation in human wound healing.
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