西格莱克
免疫系统
聚糖
神经退行性变
生物
炎症
免疫学
获得性免疫系统
受体
疾病
细胞生物学
先天免疫系统
功能(生物学)
糖蛋白
遗传学
医学
病理
作者
Matthew S. Macauley,Paul R. Crocker,James C. Paulson
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2014-09-19
卷期号:14 (10): 653-666
被引量:802
摘要
All mammalian cells display a diverse array of glycan structures that differ from those that are found on microbial pathogens. Siglecs are a family of sialic acid-binding immunoglobulin-like receptors that participate in the discrimination between self and non-self, and that regulate the function of cells in the innate and adaptive immune systems through the recognition of their glycan ligands. In this Review, we describe the recent advances in our understanding of the roles of Siglecs in the regulation of immune cell function in infectious diseases, inflammation, neurodegeneration, autoimmune diseases and cancer.
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