化学
立体化学
组胺
敌手
化学合成
生物活性
双环分子
受体
药理学
体外
生物化学
医学
作者
Giovanni Sorba,Roberta Fruttero,Antonella Di Stilo,Alberto Gasco,Marco Orsetti
标识
DOI:10.1002/ardp.19923250304
摘要
Abstract Analogues of 3‐amino‐4‐[2‐[(5‐dimethylaminomethyl‐2‐furyl)methylthio] ethylamino]furazan (1) containing carbonyl groups joined to the amino functions linked to the furazan system have been synthetized and investigated for their H 2 ‐antagonist properties on the isolated guinea pig right atrium. The presence of the carbonyl group lowers the activity in respect to the corresponding leads. The decrease in activity is only by 1‐2 orders of magnitude in the 3‐acylaminofurazan series versus inactivity in the 4‐acylamino isomers and in the diacylated series.
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