封锁
免疫系统
免疫学
间质细胞
免疫检查点
转化生长因子
CD8型
转化生长因子β
免疫疗法
生物
癌症研究
医学
受体
内科学
作者
Claire Vanpouille-Box,Silvia C. Formenti
标识
DOI：10.1016/j.it.2018.03.002
摘要
Tumors that elude infiltration by CD8+ T lymphocytes are particularly resistant to multiple forms of treatment, including immune checkpoint blockade. Stromal transforming growth factor (TGF)-β appears to play a key role in this process, potentially constituting a target for novel combinatorial regimens tackling immune-excluded neoplasms.
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