小胶质细胞
串扰
间质细胞
胞外囊泡
胶质母细胞瘤
胶质瘤
细胞生物学
细胞外小泡
细胞外
细胞内
生物
星形胶质细胞
微泡
神经科学
癌症研究
中枢神经系统
免疫学
基因
炎症
小RNA
物理
光学
生物化学
作者
Lisa Nieland,Liza M. Morsett,Marike L. D. Broekman,Xandra O. Breakefield,Erik R. Abels
标识
DOI:10.1016/j.tins.2020.10.014
摘要
Glioblastoma the most aggressive form of brain cancer, comprises a complex mixture of tumor cells and nonmalignant stromal cells, including neurons, astrocytes, microglia, infiltrating monocytes/macrophages, lymphocytes, and other cell types. All nonmalignant cells within and surrounding the tumor are affected by the presence of glioblastoma. Astrocytes use multiple modes of communication to interact with neighboring cells. Extracellular vesicle-directed intercellular communication has been found to be an important component of signaling between astrocytes and glioblastoma in tumor progression. In this review, we focus on recent findings on extracellular vesicle-mediated bilateral crosstalk, between glioblastoma cells and astrocytes, highlighting the protumor and antitumor roles of astrocytes in glioblastoma development.
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