二苯甲酮
对映选择合成
亚胺
化学
卡宾
胍
催化作用
药物化学
组合化学
立体化学
有机化学
作者
Jian Yang,Peiran Ruan,Wei Yang,Xiaoming Feng,Xiaohua Liu
出处
期刊:Chemical Science
[The Royal Society of Chemistry]
日期:2019-01-01
卷期号:10 (44): 10305-10309
被引量:23
摘要
Efficient enantioselective insertion of α-diazoesters into the N-H bond of N-sp2-hybridized benzophenone imine was realized by using Rh2(esp)2 and chiral guanidine cooperative catalysis. Both aliphatic and aromatic substituted α-amino esters were obtained in high yields (up to 99%) and good enantioselectivities (up to 95.5 : 4.5 er) under mild reaction conditions.
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