Mechanisms of the effects of gut microbiome on the central nervous system

Recently, An increasing number of studies have suggested that interaction between gut microbiome and central nervous system is bidirectional.It is known that altered emotional state and chronic stress can change the composition of gut microbiome, while gut bacteria can impact neurological development, alter behavior and potentially affect the onset and/or severity of nervous system disorders.The review will expound the potential underlying mechanisms from the following several aspects: the effect of gut microbiota on Intestinal permeability, the effect of bacterial metabolites on the central, how the microbiome Influence blood brain barrier integrity, how the gut microbiota regulate neurotransmitter levels, how the microbial control neurological function by the immune system and whether the vagus nerve can act as a mediator of the effect of gut. Key words: Gut microbiome; Central Nervous System; Gut-Brain axis; Mechanism; Behavior