产热
骨形态发生蛋白
生物
葡萄糖稳态
胰岛素抵抗
能量稳态
脂肪生成
平衡
脂肪组织
调节器
FGF21型
内分泌学
医学
内科学
胰岛素
肥胖
成纤维细胞生长因子
受体
遗传学
基因
作者
Ritesh K. Baboota,Matthias Blüher,Ulf Smith
出处
期刊:Diabetes
[American Diabetes Association]
日期:2021-01-14
卷期号:70 (2): 303-312
被引量:13
摘要
Bone morphogenetic proteins (BMPs) are a group of signaling molecules that belong to the TGF-β superfamily. Initially discovered for their ability to induce bone formation, BMPs are known to play a diverse and critical array of biological roles. We here focus on recent evidence showing that BMP4 is an important regulator of white/beige adipogenic differentiation with important consequences for thermogenesis, energy homeostasis, and development of obesity in vivo. BMP4 is highly expressed in, and released by, human adipose tissue, and serum levels are increased in obesity. Recent studies have now shown BMP4 to play an important role not only for white/beige/brown adipocyte differentiation and thermogenesis but also in regulating systemic glucose homeostasis and insulin sensitivity. It also has important suppressive effects on hepatic glucose production and lipid metabolism. Cellular BMP4 signaling/action is regulated by both ambient cell/systemic levels and several endogenous and systemic BMP antagonists. Reduced BMP4 signaling/action can contribute to the development of obesity, insulin resistance, and associated metabolic disorders. In this article, we summarize the pleiotropic functions of BMP4 in the pathophysiology of these diseases and also consider the therapeutic implications of targeting BMP4 in the prevention/treatment of obesity and its associated complications.
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