白藜芦醇
氧化应激
血脂异常
炎症
医学
内科学
糖尿病
内分泌学
骨关节炎
2型糖尿病
2型糖尿病
链脲佐菌素
药理学
病理
替代医学
作者
Hasnaa Ali Ebrahim,Norah M Alzamil,Bahjat Al‐Ani,Mohamed A Haidara,Samaa Samir Kamar,Amal F Dawood
标识
DOI:10.1080/13813455.2020.1771378
摘要
Background: We investigated whether the anti-inflammatory and antioxidant agent, resveratrol can inhibit type 2 diabetes mellitus (T2DM)-induced osteoarthritis (OA) in rats and whether it is associated with the suppression of glycaemia, dyslipidemia and inflammatory and oxidative stress biomarkers.Materials and methods: T2DM was induced by streptozotocin (50 mg/kg body weight) and high carbohydrate and fat diet (HCFD). The protective group was put on resveratrol (30 mg/kg) 14 days prior to the induction of diabetes and continued on resveratrol and HCFD until being sacrificed at week 12.Results: Diabetic rats showed a substantial damage to the knee joints and loss of proteoglycans from the articular cartilage, which were effectively but not completly protected by resveratrol. Resveratrol also significantly (p ≤ .0029) reduced diabetic up-regulation of HbA1c, hyperlipidaemia, inflammation and oxidative stress.Conclusions: Resveratrol protects against T2DM-induced OA associated with the inhibition of glycated haemoglobin, dyslipidemia, and biomarkers of oxidative stress and inflammation.
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