内科学
医学
心脏病学
脑源性神经营养因子
射血分数
心力衰竭
心肌梗塞
神经营养因子
亚临床感染
人口
内分泌学
受体
环境卫生
作者
Martin Bahls,Stephanie Könemann,Marcello R. P. Markus,Kristin Wenzel,Nele Friedrich,Matthias Nauck,Henry Völzke,Antje Steveling,Deborah Janowitz,Hans‐Jörgen Grabe,Stephan B. Felix,Marcus Dörr
标识
DOI:10.1038/s41598-019-51776-8
摘要
Abstract The brain-derived neurotrophic factor (BDNF) is a neuronal growth factor essential for normal cardiac contraction and relaxation. Alterations in BDNF signaling are related to the development of cardiovascular disease. Whether BDNF is related to subclinical cardiac remodeling is unclear. We related BDNF with echocardiographic parameters and NTproBNP in a large population-based cohort (n = 2,976, median age 48 years; 45% male). Transthoracic echocardiography was performed on all subjects and BDNF was measured by ELISA. Study participants with severe kidney dysfunction, previous myocardial infarction, and LV ejection fraction <40% were excluded. Linear regression models were adjusted for age, sex, lean mass, fat mass, current smoking, systolic blood pressure and depression. Low BDNF was associated with high NTproBNP. A 10,000 pg/ml lower BDNF was related with a 2.5 g higher (95%-confidence interval [CI]: 0.2 to 4.9; p = 0.036) LV mass, 0.01 cm posterior wall thickness (0.003 to 0.022; p = 0.007) and 0.02 E/A ratio (0.003 to 0.042, p = 0.026). Here we show that low BDNF levels are related with adverse cardiac remodeling and higher levels of NTproBNP. Further research is warranted to assess if BDNF may be used to monitor neuronal-cardiac damage during CVD progression.
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