心肺适能
脂肪肝
医学
脂肪变性
内科学
脂肪组织
优势比
代谢综合征
减肥
内分泌学
体质指数
胃肠病学
心脏病学
肥胖
疾病
作者
Kοnstantinos Kantartzis,Claus Thamer,Andreas Peter,Jürgen Machann,Fritz Schick,Christina Schraml,Alfred Königsrainer,Ingmar Königsrainer,Stefan Kröber,Andreas Nieß,Andreas Fritsche,Hans‐Ulrich Häring,Norbert Stefan
出处
期刊:Gut
[BMJ]
日期:2008-12-11
卷期号:58 (9): 1281-1288
被引量:245
标识
DOI:10.1136/gut.2008.151977
摘要
Objective:
Lifestyle intervention with diet modification and increase in physical activity is effective for reducing hepatic steatosis in patients with non-alcoholic fatty liver disease (NAFLD). However, for a similar weight loss, there is a large variability in the change in liver fat. We hypothesised that cardiorespiratory fitness may predict the response to the intervention. Design:
Longitudinal study with increase in physical activity and diet modification. Setting:
University teaching hospital. Patients:
50 adults with NAFLD and 120 controls at risk for metabolic diseases. Main outcome measures:
Total-, subcutaneous abdominal- and visceral adipose tissue by magnetic resonance tomography, liver fat by 1HMR spectroscopy and cardiorespiratory fitness (VO2,max) by a maximal cycle exercise test at baseline and after 9 months of follow-up. Results:
In all subjects total-, subcutaneous abdominal- and visceral adipose tissue decreased and fitness increased (all p<0.0001) during the intervention. The most pronounced changes were found for liver fat (−31%, p<0.0001). Among the parameters predicting the change in liver fat, fitness at baseline emerged as the strongest factor, independently of total- and visceral adipose tissue as well as exercise intensity (p = 0.005). In the group of subjects with NAFLD at baseline, a resolution of NAFLD was found in 20 individuals. For 1 standard deviation increase in VO2,max at baseline the odds ratio for resolution of NAFLD was 2.79 (95% confidence interval, 1.43–6.33). Conclusions:
Cardiorespiratory fitness, independently of total adiposity, body fat distribution and exercise intensity, determines liver fat content in humans, suggesting that fitness and liver fat are causally related to each other. Moreover, measurement of fitness at baseline predicts the effectiveness of a lifestyle intervention in reducing hepatic steatosis in patients with NAFLD.
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