天麻素
天麻
神经保护
小胶质细胞
神经病理学
转基因小鼠
医学
药理学
莫里斯水上航行任务
神经炎症
神经科学
转基因
疾病
化学
中医药
免疫学
海马体
病理
生物
内科学
生物化学
炎症
替代医学
色谱法
基因
作者
Yunzi Hu,Chengyan Li,Wei Shen
摘要
Alzheimer's disease ( AD ) is a progressive, neurodegenerative disease, characterized by excessive accumulation of amyloid‐beta (Aβ) and activation of microglia cells and astrocytes. In this research, we evaluated whether gastrodin, an active component isolated from the rhizome of Gastrodia elata , has neuroprotective effects in a mouse model of AD , Tg2576 mice. Treatment of gastrodin (60 mg/kg for 15 days) significantly improved memory impairments in the M orris water maze test and probe test. Moreover, immunohistochemical and ELISA results indicated that gastrodin significantly attenuated Aβ deposition and glial activation in brains of these transgenic mice. These findings suggested that gastrodin exerted neuroprotective activity via anti‐inflammatory and anti‐amyloidogenic effects and that gastrodin may be a potential option for AD therapy.
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