丝素
止血剂
止血
生物材料
丝胶
生物粘附
止血器
止血剂
丝绸
外科
生物医学工程
医学
材料科学
纳米技术
药物输送
复合材料
作者
Md. Tipu Sultan,Heesun Hong,Ok Joo Lee,Olatunji Ajiteru,Young Jin Lee,Ji Seung Lee,Hanna Lee,Soon Hee Kim,Chan Hum Park
出处
期刊:Biomolecules
[MDPI AG]
日期:2022-04-30
卷期号:12 (5): 660-660
被引量:21
摘要
Hemostasis plays an essential role in all surgical procedures. Uncontrolled hemorrhage is the primary cause of death during surgeries, and effective blood loss control can significantly reduce mortality. For modern surgeons to select the right agent at the right time, they must understand the mechanisms of action, the effectiveness, and the possible adverse effects of each agent. Over the past decade, various hemostatic agents have grown intensely. These agents vary from absorbable topical hemostats, including collagen, gelatins, microfibrillar, and regenerated oxidized cellulose, to biologically active topical hemostats such as thrombin, biological adhesives, and other combined agents. Commercially available products have since expanded to include topical hemostats, surgical sealants, and adhesives. Silk is a natural protein consisting of fibroin and sericin. Silk fibroin (SF), derived from silkworm Bombyx mori, is a fibrous protein that has been used mostly in fashion textiles and surgical sutures. Additionally, SF has been widely applied as a potential biomaterial in several biomedical and biotechnological fields. Furthermore, SF has been employed as a hemostatic agent in several studies. In this review, we summarize the several morphologic forms of SF and the latest technological advances on the use of SF-based hemostatic agents.
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