心肌梗塞
外渗
免疫系统
结扎
心室重构
医学
炎症
细胞
免疫
梗塞
生物
免疫学
心脏病学
内科学
遗传学
作者
Kaiyu Jin,Shan Gao,Penghui Yang,R. S. Guo,Dan Li,Yunsha Zhang,Xiaoyan Lu,Guanwei Fan,Xiaohui Fan
标识
DOI:10.1002/smtd.202100752
摘要
Myocardial infarction (MI) is strongly associated with the temporal regulation of cardiac immunity. However, a variety of current clinical trials have failed because of the lack of post-MI immunomodulating/anti-inflammatory targets. Single-cell RNA sequencing analysis of the cardiac Cd45+ immune cell at 0, 3, 7, and 14 d after injury in a mouse left anterior descending coronary artery ligation model is performed. Major immune cell populations, distinct subsets, and dynamic changes are identified. Macrophages (Mø) are most abundant, peaking at 3 d after infarction. Mø-5 and Mø-6 are the predominant infiltrated subsets at this time point, with strong expression of inflammatory factors. Further analysis demonstrates that suppressing these sets attenuated pathological MI progression by preventing subsequent leukocyte extravasation and adverse remodeling. Abundant apoptotic neutrophils and a profibrotic macrophage subset on days 7 and 14, respectively, are also detected. These results provide a basis for developing cell type- and time-specific interventions in MI.
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