光动力疗法
层状双氢氧化物
氢氧化物
材料科学
聚乙二醇
辐照
体内
活性氧
纳米技术
化学
无机化学
生物化学
有机化学
物理
核物理学
生物技术
生物
作者
Weicheng Shen,Tingting Hu,Xueyan Liu,Jiajia Zha,Fanqi Meng,Zhikang Wu,Zhuolin Cui,Yu Yang,Hai Li,Qinghua Zhang,Lin Gu,Ruizheng Liang,Chaoliang Tan
标识
DOI:10.1038/s41467-022-31106-9
摘要
Although two-dimensional (2D) layered double hydroxides (LDHs) have been widely used as efficient nanoagents for biological diagnosis and treatment, they have been found to be inert as photosensitizers (PSs) for photodynamic therapy (PDT). Herein, we report the defect engineering of ultrathin 2D CoMo-LDH and NiMo-LDH nanosheets as highly active inorganic PSs for PDT in the third near-infrared (NIR-III) window. Hydrothermal-synthesized 2D CoMo-LDH and NiMo-LDH nanosheets are etched via a simple acid treatment to obtain defect-rich CoMo-LDH and NiMo-LDH nanosheets. Importantly, the defect-rich CoMo-LDH nanosheets exhibit much higher activity (~97 times) for generation of reactive oxygen species than that of the pristine CoMo-LDH nanosheets under a NIR-III 1567 nm laser irradiation. Therefore, after modification with polyethylene glycol, the defect-rich CoMo-LDH nanosheets can be used as an efficient inorganic PS for PDT to efficiently induce cancer cells apoptosis in vitro and eradicate tumors in vivo under 1567 nm laser irradiation.
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