Cryo‐EM Structure of FcεRI Bound IgE Reveals Multiple Defined Conformations of the Fab‐Fc Hinge

Our data reveal the architecture of a full-size IgE antibody bound to its receptor and a new layer of dynamics in FcεRIα bound IgE on top of the well-established IgE Fc conformations. Development of novel anti-IgE therapeutics may take into account these properties of FcεRIα bound IgE.